Peptide Watchdogs
Price index / Argireline
Cosmetic

Argireline

Also known as acetyl hexapeptide-8

CAS 616204-22-9 Also sold as Acetyl Hexapeptide-8, Acetyl Hexapeptide-3, AH-8

A cosmetic research peptide. Current market pricing by vial size, and vendor listings as they are verified.

For research use only. Not for human consumption. No health, dosing, or usage claims are made.

What Argireline is

Argireline (acetyl hexapeptide-8, also called acetyl hexapeptide-3) is a synthetic, N-acetylated hexapeptide derived from a fragment of the SNAP-25 protein, marketed since 2001 as a topical cosmetic anti-wrinkle ingredient. In the literature it is proposed to reduce facial-muscle contraction by interfering with SNARE-complex vesicle fusion, though clinical evidence is mixed. It is a cosmetic ingredient, not an FDA-approved drug.

Type6 amino acids (a hexapeptide)
Molecular formulaC34H60N14O12S
Molecular weight889.00 g/mol (free peptide; the acetate salt sold in cosmetics is heavier, ~949 g/mol)
CAS number616204-22-9
Amino-acid sequenceAc-Glu-Glu-Met-Gln-Arg-Arg-NH2 (N-terminally acetylated, C-terminal amide)
CategoryCosmetic

Regulatory status: Argireline is handled as a cosmetic ingredient rather than a drug; it is not FDA-approved as a therapeutic and carries no approved medical claims. It is used topically in over-the-counter cosmetic products.

Vial price (low)
$30
Vial price (high)
$120
Vial sizes
10, 50 mg
Vendors listing
—
Verified
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Price by vial size

sourced market ranges · Jul 2026
10 mg vial
$30–$60
50 mg vial
$60–$120

Typical vendor vial prices, Jul 2026. Exact prices load with verified listings.

Compare vendors

vendor prices · lowest first
VendorVial priceCoupon
Simple Peptide
$0.05Best — View vendor ›
Precision Research Peptides
$0.13 WATCHDOG20 View vendor ›
Prime Lab Peptides
$0.16 — View vendor ›
Koi Peptides
$0.18 — View vendor ›
Protide Health
$0.20 — View vendor ›
BioInfinity Lab
$0.22 — View vendor ›
Kaia Peptides
$0.33 — View vendor ›
BioLongevity Labs
$0.50 — View vendor ›
Mile High Compounds
$1 — View vendor ›
PSPeptides
$3.60 — View vendor ›
Skye Peptides
$8.80 — View vendor ›
Comparing vial prices. Vial price is what you actually pay — no derived math to get wrong. Just match the vial size across vendors: a 10 mg vial against another 10 mg vial. Sizes for this compound are listed above. Need to plan a reconstitution? Use the calculator.

Where it shows up in research

literature areas · not a health claim
Cosmetic anti-wrinkle formulation researchSNARE-complex and neurotransmitter-release studiesTopical peptide skin-permeability research

These are areas where the compound appears in the scientific and cosmetic-science literature. Listing a research area is not a health claim and does not indicate any effect you should expect.

Storage & handling

Planning a reconstitution? Use the calculator — it is math for handling a vial, not dosing.

Looking at this for yourself? Argireline is a research compound — whether it is right for a person is a medical question we cannot answer. Talk to a licensed clinician. Everything on this page is for laboratory research use only.

Sources & further reading: PubChem CID 11228338 — acetyl hexapeptide-8 identity (NCBI) · Acetyl hexapeptide-3 — overview (Wikipedia) · Argireline cosmetic review (PubMed 40196949)
How we source this ›

Frequently asked

How much does Argireline cost?
About $30–$120 per vial, depending on vial size. Compare the same size across vendors.
Why do Argireline prices vary so much?
Vial sizes differ, so always compare the same vial size across vendors. Batch testing, stock, and pack discounts move the true cost too — see what "Verified" means.
How are Argireline vendors verified?
A vendor earns a Verified badge only after independent batch testing (HPLC purity + mass-spec identity) checks out against its COA. Verification is never for sale.

Related compounds

Cosmetic
GHK-Cu $40+ / vial Melanotan 2 $55+ / vial SNAP-8 $45+ / vial